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Mouse strains

Strains and stocks of mice most widely used in biomedical research are listed in Table 1. This is based on a PubMed search of the number of papers using the designated strain or stock for the years 2001-2005. Note that "genetically defined" (inbred, transgenic, knockout and congenic) mice were cited on about 2/3rds of occasions, but many of these will have had an inbred strain genetic background. Straight inbred strains accounted for about 1/3rd. of citations.

Individual inbred strains cited are listed in Table 2 in descending order of popularity. Strain BALB/c is clearly the most popular strain, followed by the two major sub-strains of C57BL. Together these account for approximately 2/3rds of all times that a strain is chosen..

A list of inbred strains and their characteristics is maintained on the Jackson Laboratory web site.

The International Mouse Strain Resource (IMSR) ".. is a searchable online database of mouse strains and stocks available worldwide, including inbred, mutant, and genetically engineered mice. The goal of the IMSR is to assist the international scientific community in locating and obtaining mouse resources for research. Note that the data content found in the IMSR is as it was supplied by data provider sites." Click here for access.

The Mouse Phenome Database is a compilation of comparative phenotypic data on mouse inbred strains.

Extensive additional information is also available on the Jackson Laboratory main web site .

Table 1. Types of mice and frequency of  citations in the  PubMed  bibliographic database, 2001-2005

Type

Number of citations

Percent

Mice, inbred strains

60,404

33.6

Mice, transgenic

37,181

20.7

Mice, knockout

22,965

12.8

Mice, congenic

403

0.2

Mice, none of above

59,062

32.8

Total

180,015

100

 

Table 2. Inbred strains of mice and frequency of  citations in the  PubMed  bibliographic database

MESH heading

Mice, inbred strains

Number of times cited

Pecent (of inbreds)

Yes

BALB/c

20,421

36.4

Yes*

C57BL/6

10,279

18.3

Yes*

C57BL/10

6251

11.1

Yes

C3H

3764

6.7

Yes

ICR

3502

6.2

Yes

CBA

2167

3.9

Yes

A/J

1771

3.2

Yes

NOD

1722

3.1

Yes*

DBA/1

1199

2.1

Yes*

DBA/2

1178

2.1

No

MOLD

877

1.6

No

129

619

1.1

Yes

HRS

479

0.9

Yes

MRL

411

0.7

Yes

NZB

294

0.5

No

NIH

291

0.5

Yes

AKR

290

0.5

No

SJL

200

0.4

No

NZW

112

0.2

No

CAST

76

0.1

No

KK

58

0.1

Yes

SENCAR

56

0.1

No

C57L

36

0.1

No

SAMR1

31

0.1

No

SAMP1

30

0.1

No

C57BR

11

0

No

NZO

10

0

-

Total

56,135

100

* PubMed does not distinguish between sublines